报告题目：Recent Progress on Activatable Photosensitizers and Fluorescent Probes

报告人：Juyoung Yoon 教授

邀请人：李林 教授

报告时间：12月8日（星期二）9:00

报告地点：科技创新大楼C501

摘要

Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine. Here, we develop a “one-for-all” nanomaterial (NanoPcTBs) that self-assembles from flexible and versatile phthalocyanine building blocks. Fluorescence and reactive oxygen species (ROS) generation could be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT). We also reported a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which have the capability of undergoing nucleic acid-responsive disassembly. On the other hand, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, was recently confirmed using an inducible transgenic mouse system. In a recent investigation, we devised a novel molecular design approach to create heavy-atom-free photosensitizers for enhanced photodynamic therapy under hypoxia conditions. The thionaphthalimides display dramatically enhanced quantum yields for photosensitized singlet oxygen formation (Φ_∆ ~ 1.00, in air-saturated acetonitrile). Finally, recent progress from our group on the fluorescent probes based on N-heterocyclic carbene (NHC) boranes for HOCl will be also presented.

个人简介

Prof. Juyoung Yoon，韩国梨花女子大学化学与纳米科学院杰出教授，韩国科学院院士。在荧光探针、分子识别、生化传感器以及新型有机功能材料等研究方向取得了卓越的成就，在韩国和国际上享有较高知名度和影响力。目前已在Chem. Rev., Chem. Soc. Rev., Chem, J. Am. Chem. Soc., Angew. Chem. Int. Ed.等杂志发表学术论文380余篇，H-index 103，他引超过41000次。自2014年至今，连续7年被评为全球高被引科学家（highly cited researcher）。