教授，硕士生导师

联系方式：Email: iamjhliu@njtech.edu.cn

教育工作经历

2007年毕业于黑龙江大学，同年进入湖南大学攻读硕士和博士学位，之后在香港大学开展博士后工作，2015年12月加入南京工业大学先进材料研究院。

学术成绩

主要聚焦于光电生物传感方面的研究。近年来，以第一/通讯或合作者身份在Nat.Commun.、Adv. Mater.、ACSNano、Anal. Chem.、Biosens. Bioelectron.、ACS Appl. Mater. Inter.、Sensor Actuat B-Chem.、Chem. Commun.和Talanta等SCI 期刊发表论文50多篇，同行引用2000余次；主持国家自然科学基金三项、省级项目/开放课题/横向课题项目多项。担任Adv. Mater., Adv.Funct. Mater., Anal. Chem., Biosens. Bioelectron., ACS Appl. Mater. Inter., Sensor Actuat B-Chem., Small等期刊的审稿人。

研究方向

聚焦于光电生物传感芯片研究，（1）荧光纳米材料的合成及传感应用；（2）多维柔性光/电生物芯片的研发; （3）实时/快速体外诊断试剂盒的开发;发展面上国家大健康的早期疾病诊断新技术和新方法。

科研项目

1. 国家自然科学基金面上项目：信号放大纸基生物芯片研制及多心肌标志物同步检测，在研，主持

2. 国家自然科学基金青年项目：针对肝癌标志物的光电化学核酸传感器设计和应用研究，结题，主持

3. 国家自然科学基金专项项目：以石墨烯为基底的多重信号放大SERS传感研究，结题，主持

代表性论文：

1. H. Yang, S. Zhu, L. Pang, Y. Ma, X. Liu, J. Liu*, Cu²⁺-triggered wavelength-tunable real-time in situ fluorogenic immunoassay for detection of cTnI in human serum, Sensors&Actuators: B. Chemical, 2024, 406,135388.

2. Q. Ci, H. Yang, Y. Bian, Z. Li, J. Liu*, J. Wei, N.Yang, J. Chen, L. Li *, C.Zhang*, An in situ fluorescent copolymer dots-based kit for the specific detection of monoamine oxidase-A in cell/tissue/human prostate cancer, Sensors&Actuators: B. Chemical, 2023, 397,134655.

3. L.Zhang#, Q. Wu#, M. Ren, H. Zhang, X. Zhang, J. Liu*, and Z. Fu*, N-Heterocyclic Carbene-Catalyzed Atroposelective Synthesis of 5-Indo-1-yl Pyran-2-ones with an N-C axis from Enals, Adv. Synth. Catal. 2023, 365, 1-7.

4. W.Ma, L. Pang, J. Liu*, L. Wen, H. Ma, Y.Li*, Z. Xu, C. Zhang, and H. Yu*, MnO₄⁻‑triggered immediate-stable real-time fluorescence immunosensor with high response speed and low steady-state error, Analytical Chemistry. 2023, 95, 6323-6331.

5. Y. Sun#, L.Wen#, H.Ma#, W. Ma, Z. Fu, Yinhui Li*, C. Zhang, L. Li, J. Liu*, Engineering trienzyme cascade-triggered fluorescent immunosensor platform by sequentially integrating alkaline phosphatase, tyrosinase and horseradish peroxidase, Chinese Chemical Letters, 2023, 34, 107654.

6. F. Geng #, X. Liu #, T. Wei, Z. Wang, J. Liu*, C. Shao, G. Liu, M. Xu *, L. Feng*, An alkaline phosphatase-induced immunosensor for SARS-CoV-2 N protein and cardiac troponin I based on the in situ fluorogenic self-assembly between N-heterocyclic boronic acids and alizarin red S, Sensors&Actuators: B. Chemical, 2023, 378,133121.

7. Z. Hu, # C. Wei, # Q. Shi, # X. Hong, # J. Liu, #(共一) X. Zhou, J. Han, W. Cao, A. Gupta, X. Zhang, D.Wei*, Z. Fu*, W.Huang, Desymmetrization of N-Cbz Glutarimides through N-Heterocyclic Carbene Organocatalysis, Nature Communications, 2022, 13, 4042.

8. J. Liu*, G. Ruan, W. Ma, Y. Sun, H. Yu, Z.Xu, C.Yu, H. Li, C. Zhang,* and L. Li,* Horseradish peroxidase-triggered direct in situ fluorescent immunoassay platform for sensing cardiac troponin I and SARS-CoV-2 nucleocapsid protein in serum. Biosensors and Bioelectronics. 2022,198,113823.

9. L. Ke, # J. Liu, # (共一) Y.Hu, X. Zhang, X.Zhang, Y. Wang, Y. Luo, W. Wang, Y.Yan,* H. Lin, K. Rui, J. Zhu,* and Y. Zhu*, Compressive space dynamics manipulation enabling wearable fiber sensors for highly sensitive human micromotion monitoring, Adv. Mater. Technol., 2022, 2101544

10. X. Hong, # J. Guo, # J. Liu, #(共一)W. Cao, C. Wei, Y. Zhang, X. Zhang, Z. Fu*. Organocatalytic Dynamic Kinetic Resolution of N-Arylindole Lactams: Atroposelective Construction of Axially Chiral Amino Acids Bearing a C-N Chiral Axis, SCIENCE CHINA Chemistry, 2022, 65,905-911.

11. C. Chen, G. Ruan, Y. Sun, L. Wang,* C. Zhang, J. Liu,* In situ Cu²⁺-triggered wavelength-tunable fluorescent sensor for highly sensitive sensing inorganic pyrophosphatase activity and its logic gate application, Sensors&Actuators: B. Chemical, 2021, 346,130439.

12. Q. Ci, X. Qin, J. Liu*, R. Wang, Z. Li, W. Qin, K. Lim, C. Zhang* and L. Li*, Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model, Chem.Comm., 2020, 56, 11823-11826.

13. J. Liu*, C.Zou, C.Chen, H. Fang, Q. Wu, H. Yu, J. Zhu*, L. Li*, S. Yang, W. Huang, Topochemical assembly of levodopa nanoparticles network as a high performance biosensing platform coupling with π-π stacking and electrostatic repulsion interactions, Talanta, 2020, 219, 121285.

14. C. Chen, C. Zou, L. Li, H. Yu, J. Zhu, J. Liu*, Wei Huang, Blue and green emission-transformed fluorescent copolymer: Specific detection of levodopa of anti-Parkinson drug in human serum, Talanta, 2020, 214, 120817.

15. Y. Jiao, C. Du, L. Zong, X. Guo, Y. Han, X. Zhang, L. Li, C. Zhang, Q. Ju, J. Liu*, H. Yu*, W.Huang*, 3D vertical-flow paper-based device for simultaneous detection of multiple cancer biomarkers by fluorescent immunoassay, Sensors & Actuators: B. Chemical, 2020, 306,127239.

16. F. Geng, C. Zou, J. Liu,* X. Guo, Y. Fan,* H.Yu, S. Yang, Z. Liu,* L. Li, Development of luminescent nanoswitch for sensing of alkaline phosphatase in human serum based on Al³⁺-PPi interaction and Cu NCs with AIE properties, Anal. Chim. Acta., 2019,1076, 131-137.

17. C. Chen, F. Geng, Y. Wang,* H. Yu, L. Li, S. Yang, J. Liu,* W.Huang, Design of a nanoswitch for sequentially multi-species assay based on competitive interaction between DNA-templated fluorescent copper nanoparticles, Cr³⁺ and pyrophosphate and ALP, Talanta, 2019, 205, 120132.

18. X. Guo, L.Zong,Y. Jiao,Y. Han, X. Zhang, J. Xu, L. Li, C. Zhang, Z. Liu, Q. Ju, J. Liu,* Z. Xu,* H. Yu,* W. Huang*, Signal-Enhanced Detection of Multiplexed Cardiac Biomarkers by a Paper-Based Fluorogenic Immunodevice Integrated with Zinc Oxide Nanowires, Anal. Chem. 2019, 91, 9300-9307.

19. L. Gao, C.Zhu, L. Li, C. Zhang, J. Liu,* H. Yu,* W. Huang*, All paper-based flexible and wearable piezoresistive pressure sensor, ACS Appl. Mater. Interfaces, 2019, 11, 25034-25042.

20. Q. Ci, J. Liu, * X. Qin, L. Han, H. Li, H. Yu, K. Lim, C. Zhang, * L. Li,* W. Huang, Polydopamine dots-based fluorescent nanoswitch assay for reversible recognition of glutamic acid and Al³⁺ in human serum and living cell, ACS Appl. Mater. Interfaces, 2018, 10, 35760-35769.

21. S. Zhang, #C. Chen, # X. Qin, Q. Zhang, J. Liu,* J. Zhu, Y. Gao, L. Li, W. Huang, Ultrasensitive detection of trypsin activity and inhibitor screening based on the electron transfer between phosphorescence copper nanocluster and cytochrome c, Talanta, 2018, 189, 92-99.

22. Q. Zhang, D. Zhao, C. Zhang, J. Liu,* Z. An, X. Qin, Y. Gao,* S. Zhang, L. Li,* W. Huang. An effective signal amplifying strategy for copper (II) sensing by using in situ fluorescent proteins as energy donor of FRET. Sensor Actuat B: Chem., 2018, 259, 633-641.

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