余昌敏，教授，博士生导师

生物电子材料研究所 所长

联系方式

课题组主页：https://www.x-mol.com/groups/yuchangmin

办公地点：南京市新模范马路5号，南京工业大学丁家桥校区科创D楼1602

联系电话：+86-15820250571

Email：iamcmyu@njtech.edu.cn

学习工作经历

2018.04 至今：南京工业大学，柔性电子（未来技术）学院&先进材料研究院，教授

2013.12 - 2016.01：新加坡国立大学，化学系，博士后

2013.08 - 2017.12：华南理工大学，材料学院，讲师

2008.09 - 2013.07：华南理工大学，材料学专业，博士

2004.09 - 2008.07：安徽大学，高分子材料专业，学士

研究方向

（1）柔性生物电子传感器开发及应用

（2）有机荧光分子探针合成及生物成像

（3）活性药物分子智能递送体系构建

主要学术成绩

课题组主要从事柔性生物电子材料的开发和应用。面向临床疾病的诊疗需求，结合柔性生物电子和有机电子技术前沿，解决电子器件在疾病诊疗中的关键科学问题，为生物有机电子在健康医疗中的应用提供新的思路。迄今在 Adv. Mater., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Allergy, Adv. Healthc. Mater., Small等国际期刊上发表SCI论文80余篇。其中，2篇代表作被评为“ESI高被引论文”，论文总被引3500余次，H-index 31。申请/授权专利20余件。先后入选南京市留学人员科技创新人才项目（2019）、“创业浦口”英才计划团队（2020）和“南太湖精英计划”领军型创新创业团队（2022）。已主持省部级及以上项目10余项。指导研究生多次获得校优秀毕业生、国家奖学金、时钧奖学金、省科创项目等。近三年，连续担任本科生专业导师，指导学生均获得省级和校级大创项目。课题组毕业生主要进入国内外高校读博和巴斯夫、药明康德、药石等知名企业工作。热烈欢迎柔性电子学、化学、材料学和生物学等专业背景的同学加入课题组，共同进步！

近期代表性论文

1. Zhongting Zhao^#, Zheng Li^#, Fangning Du, Yixin Wang, Yue Wu, Kah‑leong Lim, Lin Li, Naidi Yang*, Changmin Yu*, Chengwu Zhang*. Linking Heat Shock Protein 70 and Parkin in Parkinson’s Disease, Molecular Neurobiology, 2023, DOI: 10.1007/s12035-023-03481-x

2. Qianhui Qi^#, Jiaying Geng^#, Weizhen An, Qiong Wu, Nan Wang, Yu Zhang, Xue Li, Qian Shen*, Wei Wang*, Changmin Yu*, and Lin Li*. Stimulus-Responsive Degradation of Silica Nanoparticles for Biomedical Applications: From the Degradation Behavior to Mechanism. 2022, under review.

3. Long Zhang, Zhongxi Huang, Qian Shen, Linjie Ju, Qiong Wu, Changmin Yu*. Recent progress in small-molecule fluorescent probes for in situ imaging and detection of enzyme. Chinese Journal of Luminescence, 2023, Accepted

4. Yingying Wang, Yongxin Liu*, Qian Shen, Chang Fu, Changmin Yu*. Basophil activation test study based on magnetic separation technique and gold nanoparticle colorimetry. Materials Review, 2023, Accepted.

5. Yuxing Yang, Xiaofei Zeng, Chan Fu, Lingxiao Tan, Naidi Yang, Yongxin Liu, Qian Shen, Jifu We*, Changmin Yu*, Chen Lu*. Paper-based microfluidics and tailored gold nanoparticles for visual colorimetric detection of multiplex allergens. Analytica Chimica Acta, 2023, 1272, 341497.

6. Yue Wu^#, Zhongting Zhao^#, Naidi Yang^#, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu*, Changmin Yu*, Chengwu Zhang*. Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson's disease models by alleviating oxidative stress. Antioxidants, 2023, 12(1), 153.

7. Lihua Huang, Bicong Zhou, Changmin Yu*, Qian Shen, Zhongxi Huang, Qiong Wu, Naidi Yang, Lin Li*, and Wei Huang*. Ultrastable gold nanoparticles-based nanoplatform with mitochondria targeting and high-fidelity intracellular bioimaging enterokinase levels. Sensors Actuat. B-Chem., 2022, 372, 132666.

8. Chenhan Wang^#, Duoteng Zhang^#, Haiyan Yang^#, Liang Shi, Lin Li, Changmin Yu*, Jifu Wei*, Qiang Ding*. A light-activated magnetic bead strategy utilized in spatio-temporal controllable exosomes isolation. Front. Bioeng. Biotechnol. 2022, 10, 1006374.

9. Xiaojing Ling^#, Yongxin Liu^#, Danxuan Zhu^#, Weizhen An, Jiaying Geng, Lin Li, Changmin Yu*, Jifu Wei*. Colorimetric visualization of histamine secreted by basophils based on DSP-functionalized gold nanoparticles. Anal. Methods, 2022, 14 (27), 2698-2702.

10. Changmin Yu^#, Shuangxi Wang^#, Chenchen Xu^#, Yang Ding, Gaobin Zhang, Naidi Yang, Qiong Wu, Qicai Xiao, Limin Wang, Bin Fang, Chibin Pu, Jingyan Ge, Liqian Gao, Lin Li,* and Shao Q. Yao.* Two-photon small-molecule fluorogenic probes for visualizing endogenous nitroreductase activities from tumor tissues of a cancer patient. Adv. Healthcare Mater. 2022, 2200400.

11. Jinhua Liu*, Guotong Ruan, Wenlin Ma, Yujie Sun, Haidong Yu, Zhihui Xu, Changmin Yu, Hai Li, Chengwu Zhang*, Lin Li*. Horseradish peroxidase-triggered direct in situ fluorescent immunoassay platform for sensing cardiac troponin I and SARS-CoV-2 nucleocapsid protein in serum. Biosens. Bioelectron., 2022, 198, 11382.

12. Lihua Huang, Zonghao Sun, Qian Shen, Zhongxi Huang, Shuangxi Wang, Nai-di Yang, Gongqiang Li, Qiong Wu*, Wei Wang*, Lin Li, Changmin Yu*. Rational design of nanocarriers for mitochondria-targeted drug delivery. Chin. Chem. Lett., 2022, 33(9), 4146-4156.

13. Yongxin Liu^#, Mengda Cao^#, Zhongxi Huang^#, Changmin Yu*, Nai-Di Yang, Qiong Wu, Wenjie Duan, Yi Zhu, Ji-Fu Wei*, Li Lin*, Wei Huang. Ultrasensitive detection of IgE levels based on magnetic nanocapturer linked immunosensor assay for early diagnosis of cancer. Chin. Chem. Lett., 2022, 33(4), 1855-1860.

14. Xingwei Chen^#, Zhongxi Huang^#, Lihua Huang, Qian Shen, Nai-Di Yang, Chibin Pu*, Jinjun Shao*, Lin Li, Changmin Yu*, Wei Huang. Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging. RSC Adv., 2022, 12(3), 1393-1415.

15. Wenhui Ji^#, Jingyu Zhu^#, Wanxia Wu^#, Nanxiang Wang, Jiqing Wang, Jiansheng Wu, Qiong Wu*, Xuewen Wang, Changmin Yu, Gaofeng Wei*, Lin Li, Fengwei Huo*. Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics. Research, 2021, 9757126.

16. Bicong Zhou^#, Xiaolu Guo^#, Naidi Yang*, Zhongxi Huang, Lihuang, Huang, Zhijie Fang, Chengwu Zhang, Lin Li, Changmin Yu*. Surface engineering strategies of gold nanomaterials and their applications in biomedicine and detection. J. Mater. Chem. B, 2021, 9 (28), 5583-5598.

17. Jie Li,^# Zhe Su,^# Changmin Yu*, Yan Yuan, Qiong Wu, Jie Liu, Bo Peng, Wenbo Hu, Xiaomei Lu*, Haidong Yu, Lin Li*, Wei Huang. Recent progress in the development of sensing systems for in vivo detection of biological hydrogen sulfide. Dyes and pigments, 2021, 192, 109451.

18. Mengda Cao^#, Yongxin Liu^#, Chen Lu^#, Miao Guo, Lin Li, Changmin Yu*, Ji-Fu Wei*. Ultrasensitive detection of specific IgE based on nanomagnetic capture and separation with AuNP-anti-IgE nanobioprobe for signal amplification. Anal. Methods, 2021, 13 (22), 2478-2484.

19. Mengda Cao^#, Xisi Han^#, Chen Lu^#, Yujie Wang, Zhiqiang Xu, Shuangxi Wang, Bicong Zhou, Chengwu Zhang, Changmin Yu*, Lin Li*, Ji-Fu Wei*. A novel method for precise detection of allergen-specific IgE via immobilizing His-tagged allergens to paper-based device. Allergy, 2021, 76(2), 567-571.

20. Haixiao Fang, Meirong Wu, Wenhui Ji, Limin Wang, Yipei Chen, Ding Chen, Naidi Yang, Qiong Wu, Changmin Yu, Jie Liu, Jinhua Liu, Hua Bai*, Bo Peng, Xiao Huang, Hai-Dong Yu*, and Lin Li*. Simultaneously Detecting Monoamine Oxidase A and B in Disease Cell/Tissue Samples Using Paper-Based Devices. ACS Appl. Bio Mater., 2021, 4, 2, 1395-1402.