余昌敏，教授，博士生导师

生物电子材料研究所 所长

联系方式

课题组主页：https://www.x-mol.com/groups/yuchangmin

办公地点：南京市新模范马路5号，南京工业大学丁家桥校区科创D楼1602

联系电话：+86-15312011220

Email：iamcmyu@njtech.edu.cn

学习工作经历

2018.04 至今：南京工业大学，柔性电子（未来技术）学院&先进材料研究院，教授

2014.01 - 2015.12：新加坡国立大学，化学系，博士后

2013.08 - 2017.12：华南理工大学，材料学院，讲师

2008.09 - 2013.07：华南理工大学，材料学专业，博士

2004.09 - 2008.07：安徽大学，高分子材料专业，学士

研究方向

（1）柔性生物电子传感器开发及诊断应用；

（2）有机荧光分子探针合成及生物成像；

（3）纳米复合水凝胶智能响应体系构建及疾病调控。

主讲课程

（1）本科生：《生物电子学基础》、《柔性电子学专业导学》、《化学与生命健康》

（2）研究生：《生物光子学》

主要学术成绩

课题组主要从事柔性生物电子材料和有机分子探针的开发和应用。面向临床疾病的诊疗需求，结合柔性生物电子和有机电子技术前沿，解决光电子器件在疾病诊疗中的关键科学问题，为生物有机电子在健康医疗中的应用提供新的思路。迄今在 Adv. Mater., Angew. Chem. Int. Ed., J. Am. Chem. Soc., Allergy, ACS Nano, Small.等国际期刊上发表SCI 论文100 余篇，同行引用4400余次，H因子37，其中2篇代表性论文被评为ESI“高被引论文”。先后入选金山高层次创新创业人才（2024）、南京市留学人员科技创新人才项目（2019）、“创业浦口”英才计划团队（2020）和“南太湖精英计划”领军型创新创业团队（2022），部分研究成果已在公司实现产业转化。已主持省部级及以上项目10余项。指导研究生多次获得校优秀毕业生、校优秀毕业论文、国家奖学金、时钧奖学金、省科创项目等。近五年，连续担任本科生专业导师，指导学生均获得省级和校级大创项目。课题组研究生毕业后约50%留在本组继续攻读博士学位，其他毕业生进入巴斯夫、药明康德、药石等知名企业工作。热烈欢迎柔性电子学、化学、材料学和生物学等专业背景的同学加入课题组，共同进步！

近期代表性论文

1. Fangning Du, Zena Chen, Xiangchi Li, Xinran Hong, Likun Wang, Fengwei Cai, Naidi Yang*, and Changmin Yu*. Organelle-Targeted Photodynamic Platforms: From Icd Activation to Tumor Ablation, Chemical Communications 2025, 61, 69, 12835-12847

2. Chenlong Zhao, Linjie Ju, Lihua Huang, Changmin Yu*, Long Zhang, Hanbin Wu, Zhengyang Shi, Qian Shen, Yanan Ding, Jifu Wei*, and Lin Li*. Negatively Charged Peptides Assisted Gold Nanorod-Based Nano-Magic Bullet for Mitochondria-Targeting and Imaging-Guided Synergistic Photothermal/Dynamic Therapy. Small 2025, 2504297.

3. Weizhen An^#, Zhongxi Huang^#, Wei Jiang, Fangning Du, Chenfeng Xu, Qian Shen, Naidi Yang*, Jia Zhou*, Lin Li, Changmin Yu*. A highly specific two-photon fluorescent probe for real-time monitoring of acetylcholinesterase in neurogenic disorders in vivo, Anal. Chim. Acta. 2024, 1331, 343309.

4. Wenjie Duan, Qian Shen, Linjie Ju*, Zhongxi Huang, Jiaying Geng, Qiong Wu, Changmin Yu*, and Jifu Wei*. Homologous Tumor Cell-Derived Biomimetic Nano-Trojan Horse Integrating Chemotherapy with Genetherapy for Boosting Triple-Negative Breast Cancer Therapy, Acs Applied Materials & Interfaces 2024, 16, 34, 45523-45536.

5. Jiaying Geng^#, Zhongxi Huang^#, Qian Shen, Chenfeng Xu, Long Zhang, Cuilan Wei, Chan Fu, Weizhen An, and Changmin Yu*. Simple Design of Fluorescein-Based Probe for Rapid and in situ Visual Monitoring of Histamine Levels in Food Spoilage, Talanta 2024, 282, 126941.

6. Wei Jiang^#, Weizhen An^#, Zhongxi Huang, Chenfeng Xu, Qian Shen, Chibin Pu, Shiji Zhang, Qiong Wu, Lin Li, and Changmin Yu*. A near-Infrared Fluorescent Probe with Two-Photon Excitation for in Situ Imaging of Nqo1 in Human Colorectum Cancer Tissue. Talanta 2024, 274, 126018.

7. Linjie Ju, Zhongxi Huang, Qian Shen, Chan Fu, Shuanghe Li, Wenjie Duan, Chenfeng Xu, Weizhen An, Zhiqiang Zhai, Jifu Wei, Changmin Yu*, and Guoren Zhou. Glutathione Depletion Based Pt(Iv) Hybrid Mesoporous Organosilica Delivery System to Conquer Cisplatin Chemoresistance: A "One Stone Three Birds" Strategy. Chinese Chemical Letters 2024, 35, 10, 109450.

8. Qianhui Qi^#, Qian Shen^#, Jiaying Geng^#, Weizhen An, Qiong Wu, Nan Wang, Yu Zhang, Xue Li, Wei Wang*, Changmin Yu*, and Lin Li*. Stimuli-Responsive Biodegradable Silica Nanoparticles: From Native Structure Designs to Biological Applications. Advances in Colloid and Interface Science 2024, 324, 103087.

9. Qian Shen^#, Mengda Cao^#, Changmin Yu*, Jian Tang, Lebin Song, Yanan Ding, Linjie Ju, Ji-Fu Wei*, Lin Li*, and Wei Huang*. Biodegradable Mesoporous Organosilica-Based Nanostabilizer Targeting Mast Cells for Long-Term Treatment of Allergic Diseases. ACS Nano 2024, 18, 26, 16934-16946.

10. Qian Shen^#, Zhongxi Huang^#, Duoteng Zhang, Xingwei Chen, Fangning Du, Zhiqiang Zhou, Chan Fu, Lin Li, Naidi Yang*, and Changmin Yu*. A Novel Coumarin-Fluorescein-Based Fluorescent Probe for Ultrafast and Visual Detection of H2s in a Parkinson's Disease Model. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 2024, 306, 123567.

11. Jingqi Xin, Shupeng Han, Meichen Zheng, Chenfeng Xu, Zhongxi Huang, Bin Wang, Changmin Yu, Feifei An*, and Yu Ren*. A Nitroreductase-Responsive Nanoprobe with Homogeneous Composition and High Loading for Preoperative Non-Invasive Tumor Imaging and Intraoperative Guidance. Chinese Chemical Letters 2024, 35, 7, 109165.

12. Chenfeng Xu^#, Zhongxi Huang^#, Jia Zhou*, Wei Jiang, Jiaying Geng, Ling Zhang, Chibin Pu, Lin Li*, Changmin Yu*, and Wei Huang. Covalent Assembly-Based Two-Photon Fluorescent Probes for in Situ Visualizing Nitroreductase Activities: From Cancer Cells to Human Cancer Tissues. Biosensors & Bioelectronics 2024, 267, 116768.

13. Haiyan Yang^#, Qian Shen^#, Chenhan Wang^#, Zhangwei Wang, Duoteng Zhang, Zhongxi Huang, Yuxing Yang, Liang Shi, Jifu Wei*, Changmin Yu*, and Qiang Ding*. Liposome Fusion Assisted Delivery of Silica Nanoquenchers for Rapid Detection of Exosomal Micrornas. Sensors and Actuators B-Chemical 2024, 415, 135978.

14. Ting-En Peng, Feng Qiu, Yunwei Qu, Changmin Yu, Xiamin Cheng*, and Lin Li*. Current and Future of "Turn-on" Based Small-Molecule Copper Probes for Cuproptosis. ChemistryOpen 2023, 12, 9.

15. Chibin Pu*, Zhongxi Huang, Lihua Huang, Qian Shen*, and Changmin Yu. Label-Free Fluorescence Turn-on Detection of Histidine-Tagged Proteins Based on Intramolecular Rigidification Induced Emission. Chemistryselect 2023, 8, 10.

16. Yue Wu^#, Zhongting Zhao^#, Naidi Yang^#, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu*, Changmin Yu*, Chengwu Zhang*. Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson's disease models by alleviating oxidative stress. Antioxidants, 2023, 12(1), 153.

17. Yuxing Yang, Xiaofei Zeng, Chan Fu, Lingxiao Tan, Naidi Yang, Yongxin Liu, Qian Shen, Jifu Wei*, Changmin Yu*, and Chen Lu*. Paper-Based Microfluidics and Tailored Gold Nanoparticles for Visual Colorimetric Detection of Multiplex Allergens. Analytica Chimica Acta 2023, 1272, 341497.

18. Zhiqiang Zhou^#, Zheng Li^#, Fangning Du, Yixin Wang, Yue Wu, Kah-leong Lim, Lin Li, Naidi Yang*, Changmin Yu*, and Chengwu Zhang*. Linking Heat Shock Protein 70 and Parkin in Parkinson's Disease. Molecular Neurobiology 2023, 60, 12, 7044-7059.

19. Zhiqiang Zhou, Duoteng Zhang, Fangning Du, Weizhen An, Jingyan Ge, Changmin Yu, Naidi Yang*, Chengwu Zhang*, Kahleong Lim, and Lin Li*. Design and Synthesis of a Mitochondrial-Targeted Jnk Inhibitor and Its Protective Effect on Parkinson's Disease Phenotypes. Chembiochem 2023, 24, e202200748.

20. Xingwei Chen, Zhongxi Huang, Lihua Huang, Qian Shen, Nai-Di Yang*, Chibin Pu, Jinjun Shao*, Lin Li*, Changmin Yu*, and Wei Huang. Small-Molecule Fluorescent Probes Based on Covalent Assembly Strategy for Chemoselective Bioimaging, Rsc Advances 2022, 12, 3, 1393-1415.

21. Lihua Huang, Zonghao Sun, Qian Shen, Zhongxi Huang, Shuangxi Wang, Naidi Yang, Gongqiang Li, Qiong Wu*, Wei Wang*, Lin Li, and Changmin Yu*. Rational Design of Nanocarriers for Mitochondria-Targeted Drug Delivery. Chinese Chemical Letters 2022, 33, 9, 4146-4156.

22. Lihua Huang, Bicong Zhou, Changmin Yu*, Qian Shen, Zhongxi Huang, Qiong Wu, Naidi Yang, Lin Li*, and Wei Huang*. Ultrastable Gold Nanoparticles-Based Nanoplatform with Mitochondria Targeting and High-Fidelity Intracellular Bioimaging Enterokinase Levels. Sensors and Actuators B-Chemical 2022, 372, 132666.

23. Xiaojing Ling, Yongxin Liu, Danxuan Zhu, Weizhen An, Jiaying Geng, Lin Li*, Changmin Yu*, and Ji-Fu Wei*. Colorimetric Visualization of Histamine Secreted by Basophils Based on Dsp-Functionalized Gold Nanoparticles. Analytical Methods 2022, 14, 27, 2698-2702.

24. Jinhua Liu*, Guotong Ruan, Wenlin Ma, Yujie Sun, Haidong Yu, Zhihui Xu, Changmin Yu, Hai Li, Cheng-wu Zhang*, and Lin Li*. Horseradish Peroxidase-Triggered Direct in Situ Fluorescent Immunoassay Platform for Sensing Cardiac Troponin I and Sars-Cov-2 Nucleocapsid Protein in Serum. Biosensors & Bioelectronics 2022, 198, 113823.

25. Yongxin Liu, Mengda Cao, Zhongxi Huang, Changmin Yu, Naidi Yang*, Qiong Wu, Liang Shi, Wenjie Duan, Yi Zhu, Jifu Wei*, Lin Li*, and Wei Huang. Ultrasensitive Detection of Ige Levels Based on Magnetic Nanocapturer Linked Immunosensor Assay for Early Diagnosis of Cancer. Chinese Chemical Letters 2022, 33, 4, 1855-1860.

26. Chenhan Wang, Duoteng Zhang, Haiyan Yang, Liang Shi, Lin Li, Changmin Yu*, Jifu Wei*, and Qiang Ding*. A Light-Activated Magnetic Bead Strategy Utilized in Spatio-Temporal Controllable Exosomes Isolation. Frontiers in Bioengineering and Biotechnology 2022, 10, 3389.

27. Zhiqiang Zhou, Duoteng Zhang, Fangning Du, Weizhen An, Jingyan Ge, Changmin Yu, Naidi Yang*, Chengwu Zhang*, Kahleong Lim, and Lin Li*. Design and Synthesis of a Mitochondrial-Targeted Jnk Inhibitor and Its Protective Effect on Parkinson's Disease Phenotypes. Chembiochem 2023, 24, e202200748.