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张仁帅 ▍ZHANG Ren-Shuai
阅读次数:1888 添加时间:2017/8/15 发布: 管理员
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张仁帅,男,博士后


研究方向:

1)活性分子的设计与制备

2)基于受体的分子胞内递送策略研究


主要学术成绩:

1Zhang, R.; Yu, R.; Xu, Q.; Li, X.; Luo, J.; Jiang, B.; Wang, L.; Guo, S.; Wu, N.; Shi, D. Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective Protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry. 2017, 134, 24-33.


2Zhang, R.; Song L.; Jiang, B.; Wang, L.; Guo, S.; Wu, N.; Shi, D. Design of Antitumor Agents Containing Saccharide Based on GLUT1, and Evaluation of Antiproliferative Activity. Bioorganic & Medicinal Chemistry Letters. 2017, 27, (11), 2488-2492.


3Zhang, R.; Chen, S.; Wang, X.; Yu, R.; Li, M.; Ren, S.; Jiang, T. Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine–glucuronic acid hybrids. Carbohydrate Research. 2016, 429, 48-53.


4Zhang, R.; Chen, S.; Zhang, X.; Yu, R.; Wan, S.; Geng, M.; Jiang, T. Synthesis and evaluation of novel non-covalent binding quinazoline glycoside derivatives targeting the L858R and T790M variants of EGFR. RSC Adv. 2016, 6, 36857-36862.


5Zhang R.; Chen S.; Wu G.; Wan S.; Jiang T. Design and Synthesis of Novel EGFR Inhibitors with L-Rhamnose–Benzoxazinone Hybrids. Journal of heterocycl chemistry. 2016, 53, (5), 1563-1569.



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